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Inhibitory effect of the combination of DHPAs and Hyperbaric Oxygen on Japanese B encephalitis virus infection in mice

[Article in Chinese]

Lu MH, Xiong HE, Tan DM.

Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha 410008, China.

OBJECTIVE:

To investigate the inhibitory effect of the combination of 2,3-dihydroxypropyl-adenine (DHPAs) and hyperbaric oxygen (HBO) on Japanese B encephalitis virus infection in mice. METHODS: Mice infected P3-55 and P3-53 virus were used in the experiments. Virus was inoculated intraperitoneally to Kumming strain mice (8.5-9.5 g). Mice were divided into groups and treated in the incubation period of the infection. The duration of treatment was 5 days, and the experiments were terminated at the end of 2 weeks after treatment. The living and the dead were then counted finally. RESULTS: The intergroup comparison showed marked difference between the control group and combination of DHPAs and hyperbaric oxygen group (P < 0.025 and P < 0.01), but there was no statistical difference between other groups and the control group (P > 0.05).

CONCLUSION:

The combined treatment of (S) DHPA and/or (RS)-DHPA and HBO has inhibitory effect on Japanese encephalitis virus infection in experimental mice.

Reprinted with Permission

Brain Disorders/Neurological Index