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Hyperbaric oxygen in the treatment of refractory haemorrhagic cystitis

A J Hughes1, A P Schwarer1,a and I L Millar2

1Bone Marrow Transplant Programme, Alfred Hospital, Melbourne, Australia

2Hyperbaric Service, Alfred Hospital, Melbourne, Australia

(a)Correspondence: A/Prof AP Schwarer, Bone Marrow Transplant Programme, Alfred Hospital, Commercial Rd, Melbourne, Australia 3181

Abstract

Haemorrhagic cystitis is a common and often debilitating complication of chemotherapy for which treatment is frequently unsatisfactory. With over 80 cases reported of radiation-induced cystitis treated successfully with hyperbaric oxygen, attention is now turning to the treatment of chemotherapeutic agent-induced cystitis. We report a case of haemorrhagic cystitis occurring after autologous peripheral blood stem cell transplantation for multiple myeloma. The patient had received cyclophosphamide and busulfan and had BK and adenoviruria. The haemorrhage was refractory to multiple conventional treatments but resolved after a course of Hyperbaric Oxygen Therapy.

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