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J Neuropathol Exp Neurol 2000 Jul;59(7):575-84
Insulin-like growth factor-I promotes myelination of peripheral sensory axons.

Russell JW, Cheng HL, Golovoy D.

Department of Neurology, Veterans Administration Medical Center, University of Michigan, Ann Arbor 48109, USA.

BACKGROUND: Insulin-like growth factor-I (IGF-I) in vivo or in the presence of other permissive factors can promote myelination in the central nervous system.

CONCLUSIONS: IGF-I is important in myelination and is critical not only for initial SC ensheathment of the axon and upregulation of myelin proteins, but also for sustained myelination. Furthermore, IGF-I associated axonal size is not the sole determinant for myelination.

PMID: 10901228 [PubMed - indexed for MEDLINE]

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