Ann N Y Acad Sci 1999 Sep 14;883:124-30
IGF-I promotes peripheral nervous system myelination.
Cheng HL, Russell JW, Feldman EL.
Department of Neurology, University of Michigan, Ann Arbor 48109-0588, USA.
Insulin-like growth factor-I (IGF-I) promotes the proliferation and differentiation of Schwann cells (SC). Continued IGF-I exposure leads to enhanced P0 expression and long-term myelination. No myelination occurs in the absence of IGF-I. These data imply that IGF-I is critical not only for SC attachment and ensheathment of axons but also for long-term myelination.
PMID: 10586238 [PubMed - indexed for MEDLINE]
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