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J Neurobiol 1999 Dec;41(4):540-8 Related Articles, Links
Insulin-like growth factor-I prevents caspase-mediated apoptosis in Schwann cells.

Delaney CL, Cheng HL, Feldman EL.

Department of Neurology, University of Michigan, 200 Zina Pitcher Place, 4414 Kresge III, Ann Arbor, Michigan 48109, USA.

BACKGROUND: Both neurons and glia succumb to programmed cell death (PCD) when deprived of growth factors at critical periods in development or following injury. Insulin-like growth factor-I (IGF-I) prevents apoptosis in neurons in vitro.

CONCLUSIONS: These results suggest that IGF-I rescues Schwann Cells from apoptosis via PI 3-K signaling which is upstream from caspase activation. Copyright 1999 John Wiley & Sons, Inc.

PMID: 10590177 [PubMed - indexed for MEDLINE]

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