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Fetal Hypoxia Is Associated with Elevated Cord Serum C-Reactive Protein Levels in Diabetic Pregnancies.

Loukovaara M, Leinonen P, Teramo K, Alfthan H, Stenman UH, Andersson S.
Department of Obstetrics and Gynecology,
Helsinki University Central Hospital, Helsinki, Finland.

Maternal diabetes increases the risk of intrauterine hypoxia. Inflammation may play a role in the pathogenesis of hypoxia-related neonatal complications. We studied correlations between levels of cord serum C-reactive protein (CRP), measured by a highly sensitive immunofluorometric assay, and indices of fetal hypoxia in diabetic pregnancies. Cord serum CRP correlated positively with amniotic fluid erythropoietin and umbilical artery pCO(2). A negative correlation existed between cord serum CRP and umbilical artery pH and pO(2). Amniotic fluid erythropoietin showed an independent effect on cord serum CRP in multiple regression analysis. These data suggest that the fetus responds to hypoxia by an inflammatory reaction. Copyright 2004 S. Karger AG, Basel

PMID: 14718755 [PubMed - as supplied by publisher]